2. Anti-infection
  3. Virus Protease
  4. ML336

ML336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂，对 VEEV TC-83 CPE、VEEV V3526 CPE、VEEV 野生型 CPE 的 IC50 分别为 32、20 和 42 nM。ML336有效抑制 VEEV 诱导的三种病毒株 (TC-83、V3526 和野生型) 细胞病变效应。

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ML336 Chemical Structure

ML336 Chemical Structure

CAS No. : 1613465-33-0

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规格 价格 是否有货 数量
1 mg ￥1500
In-stock
5 mg ￥3000
In-stock
10 mg ￥4500
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

ML336 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero 76 EC50
> 50 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus TC83 containing non-structural protein 4 Q210K mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus TC83 containing non-structural protein 4 Q210K mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 CC50
> 50 μM
Compound: 45, ML336
Cytotoxicity against african green monkey Vero 76 cells after 3 days by Celltiter-Glo reagent based assay
Cytotoxicity against african green monkey Vero 76 cells after 3 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 EC50
0.02 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus V3526 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus V3526 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 EC50
0.03 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus TC83 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus TC83 infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 EC50
0.04 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus TrD infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus TrD infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 EC50
0.17 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus TC83 infected in Vero 76 cells assessed as reduction in viral titer by crystal violet staining based microplaque assay relative to untreated control
Antiviral activity against Venezuelan equine encephalitis virus TC83 infected in Vero 76 cells assessed as reduction in viral titer by crystal violet staining based microplaque assay relative to untreated control
[PMID: 25244572]
Vero 76 EC50
17 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus TC83 containing non-structural protein 2 Y102C mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus TC83 containing non-structural protein 2 Y102C mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 EC50
19 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus TC83 containing non-structural protein 2 D116N mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus TC83 containing non-structural protein 2 D116N mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 EC50
19 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus V3526 containing non-structural protein 2 Y102C mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus V3526 containing non-structural protein 2 Y102C mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
Vero 76 EC50
66 μM
Compound: 45, ML336
Antiviral activity against Venezuelan equine encephalitis virus V3526 containing non-structural protein 4 Q210K mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
Antiviral activity against Venezuelan equine encephalitis virus V3526 containing non-structural protein 4 Q210K mutant infected in Vero 76 cells assessed as reduction in virus-induced cytopathic effect after 2 days by Celltiter-Glo reagent based assay
[PMID: 25244572]
分子量

367.40

Formula

C19H21N5O3
CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 33.33 mg/mL (90.72 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7218 mL 13.6091 mL 27.2183 mL
5 mM 0.5444 mL 2.7218 mL 5.4437 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

ML336 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7218 mL 13.6091 mL 27.2183 mL 68.0457 mL
5 mM 0.5444 mL 2.7218 mL 5.4437 mL 13.6091 mL
10 mM 0.2722 mL 1.3609 mL 2.7218 mL 6.8046 mL
15 mM 0.1815 mL 0.9073 mL 1.8146 mL 4.5364 mL
20 mM 0.1361 mL 0.6805 mL 1.3609 mL 3.4023 mL
25 mM 0.1089 mL 0.5444 mL 1.0887 mL 2.7218 mL
30 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2682 mL
40 mM 0.0680 mL 0.3402 mL 0.6805 mL 1.7011 mL
50 mM 0.0544 mL 0.2722 mL 0.5444 mL 1.3609 mL
60 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL
80 mM 0.0340 mL 0.1701 mL 0.3402 mL 0.8506 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML3361613465-33-0ML 336ML-336Virus Proteasevenezuelan equine encephalitis virusVEEVVEEV TC-83 CPE VEEV V3526 CPEVEEV Wild Type CPEInhibitorinhibitorinhibit

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目录号：
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