MOMIPP

目录号: HY-119624 纯度: 99.37%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

MOMIPP，一种巨胞饮作用的诱导剂，是一种 PIKfyve 抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MOMIPP Chemical Structure

CAS No. : 1363421-46-8

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可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥3672	In-stock
1 mg	￥1142	In-stock
5 mg	￥2000	In-stock
10 mg	￥3200	In-stock
25 mg	￥5800	In-stock
50 mg	现货	询价
100 mg		询价
200 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

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MOPIPP 询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-375	IC₅₀	5.02 μM Compound: 1; MOMIPP	Antiproliferative activity against human A375 cells after 48 hrs by MTS assay Antiproliferative activity against human A375 cells after 48 hrs by MTS assay	[PMID: 29878764]
A549	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human A549 cells after 48 hrs by MTS assay Antiproliferative activity against human A549 cells after 48 hrs by MTS assay	[PMID: 29878764]
BGC-823	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay	[PMID: 29878764]
HCT-116	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay	[PMID: 29878764]
HepG2	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay	[PMID: 29878764]
MCF-10A	IC₅₀	> 10 μM Compound: 1; MOMIPP	Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29878764]
MCF7	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay	[PMID: 29878764]
MDA-MB-231	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay	[PMID: 29878764]
MDA-MB-435S	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay	[PMID: 29878764]
SK-MEL-28	IC₅₀	8.156 μM Compound: 1; MOMIPP	Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay	[PMID: 29878764]
SK-MEL-30	IC₅₀	> 10 μM Compound: 1; MOMIPP	Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay	[PMID: 29878764]
U-251	IC₅₀	1.9 μM Compound: 19, MOMIPP	Cytotoxicity against human U251 cells after 24 hrs by MTT assay Cytotoxicity against human U251 cells after 24 hrs by MTT assay	[PMID: 22335538]
U-251	GI₅₀	2.1 μM Compound: 1, MOMIPP	Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay	[PMID: 24527179]
U-251	GI₅₀	2.3 μM Compound: 1a	Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis	[PMID: 27343855]
U-251	GI₅₀	2.32 μM Compound: 1a	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay	[PMID: 27343855]
U-251	GI₅₀	2.32 μM Compound: 1a, MOMIPP	Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay	[PMID: 25654321]

体外研究
(In Vitro)

MOMIPP 可诱导强烈的巨胞饮作用，导致培养的胶质母细胞瘤细胞在低微摩尔浓度下发生细胞分裂^[1]。
在 U373 和 Hs683 细胞系中，3 μM MOMIPP 诱导细胞空泡化^[1]。
MOMIPP (10 μM) 导致葡萄糖摄取和糖酵解代谢的早期中断。MOMIPP 选择性激活 JNK1/2 应激激酶通路，导致 c-Jun、Bcl-2 和 Bcl-xL 磷酸化^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	U251 cells
Concentration:	10 μM
Incubation Time:	4 h or 24 h
Result:	Activated the JNK stress kinase pathway.

体内研究
(In Vivo)

MOMIPP (80 mg/kg；腹腔注射；每天一次；连续 15 天) 在抑制脑内胶质母细胞瘤异种移植物的进展方面表现出适度的有效性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)^[2]
Dosage:	80 mg/kg
Administration:	i.p.; once daily; for 15 consecutive days
Result:	Suppressed progression of intracerebral glioblastoma xenografts.

分子量

292.33

Formula

C₁₈H₁₆N₂O₂

CAS 号

1363421-46-8

性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 31.25 mg/mL (106.90 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4208 mL	17.1040 mL	34.2079 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.37%

选择批次：

Data Sheet (600 KB) SDS (251 KB)

COA (265 KB) HNMR (267 KB) LCMS (269 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411. [Content Brief]

[2]. Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77. [Content Brief]

MOMIPP 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4208 mL	17.1040 mL	34.2079 mL	85.5198 mL
	5 mM	0.6842 mL	3.4208 mL	6.8416 mL	17.1040 mL
	10 mM	0.3421 mL	1.7104 mL	3.4208 mL	8.5520 mL
	15 mM	0.2281 mL	1.1403 mL	2.2805 mL	5.7013 mL
	20 mM	0.1710 mL	0.8552 mL	1.7104 mL	4.2760 mL
	25 mM	0.1368 mL	0.6842 mL	1.3683 mL	3.4208 mL
	30 mM	0.1140 mL	0.5701 mL	1.1403 mL	2.8507 mL
	40 mM	0.0855 mL	0.4276 mL	0.8552 mL	2.1380 mL
	50 mM	0.0684 mL	0.3421 mL	0.6842 mL	1.7104 mL
	60 mM	0.0570 mL	0.2851 mL	0.5701 mL	1.4253 mL
	80 mM	0.0428 mL	0.2138 mL	0.4276 mL	1.0690 mL
	100 mM	0.0342 mL	0.1710 mL	0.3421 mL	0.8552 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOMIPP1363421-46-8PIKfyveFYVE domain-containing phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinaseFab1MacropinocytosisBBBJNK1/2c-JunBcl-2Bcl-xLInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MOMIPP

Customer Review

Other Forms of MOMIPP: