2. Metabolic Enzyme/Protease Anti-infection
  3. Oxidative Phosphorylation Bacterial Antibiotic
  4. Monactin

Monactin 是一种抗生素，也是单价阳离子 (包括钾、钠和锂) 的非选择性离子载体。Monactin 是从链霉菌中分离出来，并具有抗增殖活性。

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Monactin Chemical Structure

Monactin Chemical Structure

CAS No. : 7182-54-9

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规格 价格 是否有货 数量
5 mg 询价
1 mg ￥5724
3 - 4 周

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Monactin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].

体外研究
(In Vitro)

Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3].
Monactin inhibits TCF/β-catenin transcriptional activity[4].
At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Monactin 相关抗体:
体内研究
(In Vivo)

Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

750.96

Formula

C41H66O12
CAS 号
结构分类
初始来源

Streptomyces griseus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Monactin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monactin7182-54-9Oxidative PhosphorylationBacterialAntibiotictranscriptionalmactrotetralideionophorecationsantiproliferativeInhibitorinhibitorinhibit

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产品名称：
Monactin
目录号：
HY-111525
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