MPC-3100

目录号: HY-13301 纯度: 98.3%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

MPC-3100 是一种有口服生物活性的的合成第二代 Hsp90 小分子抑制剂，具有潜在的抗肿瘤活性。

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MPC-3100 Chemical Structure

CAS No. : 958025-66-6

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规格	价格	是否有货
1 mg	￥1710	In-stock
5 mg		询价
10 mg		询价

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MPC-3100 相关产品

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查看所有亚型

HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

生物活性
纯度 & 产品资料
参考文献

生物活性

MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.77 μM Compound: 28g, MPC-3100	Cytotoxicity against human A549 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human A549 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
BT-474	IC₅₀	0.55 μM Compound: 28g, MPC-3100	Cytotoxicity against human BT474 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human BT474 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
DU-145	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in DU145 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method Inhibition of human HSP90 in DU145 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method	[PMID: 22913511]
DU-145	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in DU145 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in DU145 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
DU-145	IC₅₀	0.53 μM Compound: 28g, MPC-3100	Cytotoxicity against human DU145 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human DU145 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
HCT-116	IC₅₀	0.06 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assay Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assay	[PMID: 22913511]
HCT-116	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method Inhibition of human HSP90 in HCT116 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method	[PMID: 22913511]
HCT-116	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in HCT116 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
HCT-116	IC₅₀	0.54 μM Compound: 28g, MPC-3100	Cytotoxicity against human HCT116 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human HCT116 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
HT-29	IC₅₀	0.42 μM Compound: 28g, MPC-3100	Cytotoxicity against human HT-29 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human HT-29 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
LNCaP	IC₅₀	0.51 μM Compound: 28g, MPC-3100	Cytotoxicity against human LNCAP cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human LNCAP cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
MV4-11	IC₅₀	0.25 μM Compound: 28g, MPC-3100	Cytotoxicity against human MV4-11 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human MV4-11 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI/ADR-RES	IC₅₀	4.3 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-ADR-RES cells overexpressing P-gp 1 assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-ADR-RES cells overexpressing P-gp 1 assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI-H69	IC₅₀	0.15 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-H69 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-H69 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI-N87	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in NCI-N87 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in NCI-N87 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
NCI-N87	IC₅₀	0.2 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-N87 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-N87 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
OVCAR-8	IC₅₀	0.49 μM Compound: 28g, MPC-3100	Cytotoxicity against human OVCAR8 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human OVCAR8 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]

分子量

549.44

Formula

C₂₂H₂₅BrN₆O₄S

CAS 号

958025-66-6

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 5.5 mg/mL (10.01 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8200 mL	9.1002 mL	18.2003 mL
5 mM	0.3640 mL	1.8200 mL	3.6401 mL
10 mM	0.1820 mL	0.9100 mL	1.8200 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.3%

选择批次：

Data Sheet (599 KB) SDS (393 KB)

COA (292 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Kim SH, et al. Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor. J Med Chem. 2012 Sep 13;55(17):7480-501. [Content Brief]

MPC-3100 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8200 mL	9.1002 mL	18.2003 mL	45.5009 mL
	5 mM	0.3640 mL	1.8200 mL	3.6401 mL	9.1002 mL
	10 mM	0.1820 mL	0.9100 mL	1.8200 mL	4.5501 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPC-3100958025-66-6MPC3100MPC 3100HSPHeat shock proteinsInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MPC-3100

Customer Review

MPC-3100 相关产品

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生物活性

纯度 & 产品资料

参考文献

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稀释计算器

MPC-3100 相关分类

完整储备液配制表

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MPC-3100

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MPC-3100 相关抗体

MPC-3100 相关产品

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•同靶点蛋白产品:

查看 HSP 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

MPC-3100 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

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