2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Lipoxygenase PGE synthase
  4. mPGES-1/5-LOX-IN-1

mPGES-1/5-LOX-IN-1 (compound 3j) 是一种有效的，具有口服活性的 mPGES-1 和 5-LOX 双重抑制剂，IC50 值分别为 0.92、1.89 µM。mPGES-1/5-LOX-IN-1 具有抗炎作用。

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mPGES-1/5-LOX-IN-1 Chemical Structure

mPGES-1/5-LOX-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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mPGES-1/5-LOX-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact[1].

IC50 & Target[1]

5-LOX

1.89 μM (IC50)

mPGES-1

0.92 μM (IC50)

体内研究
(In Vivo)

mPGES-1/5-LOX-IN-1 (compound 3j) (10 mg/kg; p.o.) 具有抗炎作用，可降低促炎细胞因子 (PGE2、TNF-α 和 IL-6) 的水平，且具有胃肠道安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rat[1]
Dosage: 10 mg/kg
Administration: P.o.
Result: Showed anti-inflammatory impact and inhibited serum concentrations of PGE2, TNF-α and IL-6, did not generate ulceration in the isolated rat stomach.
分子量

446.48

Formula

C20H22N4O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

mPGES-1/5-LOX-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mPGES-1/5-LOX-IN-1LipoxygenasePGE synthaseLOXProstaglandin E synthasePGE2TNF-αIL-6orally activeanti-inflammatoryInhibitorinhibitorinhibit

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