2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. MS-II-124

MS-II-124 是一种有效的、选择性的 NLRP3 抑制剂 (IC50=0.12 μM), 具有炎症和免疫调节活性，可以用于急性肺损伤 (ALI)/急性呼吸窘迫综合征 (ARDS) 的研究。

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MS-II-124 Chemical Structure

MS-II-124 Chemical Structure

CAS No. : 3037332-85-4

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MS-II-124 相关抗体

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查看 NOD-like Receptor (NLR) 亚型特异性产品:

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NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)[1].

IC50 & Target

IC50=0.12 μM (NLRP3)[1].
体内研究
(In Vivo)

MS-II-124 (10 mg/kg; i.p.; 单剂量) 在 LPS (HY-D1056) ( i.n. 滴注, 40 μg in 40 μL PBS) 诱导的 ALI/ARDS 野生型小鼠模型中减轻肺部炎症并减少免疫细胞的浸润，具有炎症和免疫调节活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ALI/ARDS WT C57BL/6 mice model[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS).
Result: Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production.
分子量

543.05

Formula

C28H28ClFN2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MS-II-124 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS-II-1243037332-85-4NOD-like Receptor (NLR)acute lung injury (ALI)acute respiratory distress syndrome (ARDS)WT C57BL/6 miceInhibitorinhibitorinhibit

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