2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Mulberrofuran H

桑葚呋喃 H 是从栽培桑树 (Morus lhou (ser.)) 中提取的 2-芳基苯并呋喃衍生物。桑葚呋喃 H 表现出对底物 L-酪氨酸的有效抑制 (IC50=4.45 µM) 和 L-DOPA (IC50=19.70 µM)。桑葚呋喃 H 也显示出强大的抗炎和抗氧化活性。

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Mulberrofuran H Chemical Structure

Mulberrofuran H Chemical Structure

CAS No. : 89199-99-5

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Mulberrofuran H 相关抗体

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mulberrofuran H is a 2-arylbenzofuran derivative from the cultivated mulberry tree (Morus lhou (ser.) Koidz.). Mulberrofuran H demonstrates potent inhibition against substrates L-tyrosine (IC50=4.45 µM) and L-DOPA (IC50=19.70 µM). Mulberrofuran H also shows potent anti-inflammatory and antioxidative activities[1][2][3].

IC50 & Target

4.45 µM (L-tyrosine); 19.70 µM (L-DOPA)[3]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Hep 3B2 IC50
> 30 μM
Compound: 5
Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay
[PMID: 19072214]
Hep 3B2 IC50
140 nM
Compound: 5
Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis
Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis
[PMID: 19072214]
Hep 3B2 IC50
15.4 μM
Compound: 5
Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA
Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA
[PMID: 19072214]
THP-1 IC50
3.2 μM
Compound: 3
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
[PMID: 24901948]
分子量

442.46

Formula

C27H22O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mulberrofuran H 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mulberrofuran H89199-99-5Dopamine ReceptorInhibitorinhibitorinhibit

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