2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. RET FGFR VEGFR c-Kit c-Met/HGFR PDGFR Raf
  4. Multi-kinase-IN-5

Multi-kinase-IN-5 (compound 15c) 是一种有前途的多激酶抑制剂。Multi-kinase-IN-5 可抑制一组蛋白激酶（RET、KIT、cMet、VEGFR1,2、FGFR1、PDGFR 和 BRAF），显示抑制百分比为 74%、31%、62%、40%、73%、74%、59% 和 69%。针对 FGFR1、VEGFR 和 RET 激酶 IC50 分别为 1.287、0.117 和 1.185 μM。

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Multi-kinase-IN-5 Chemical Structure

Multi-kinase-IN-5 Chemical Structure

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     可免费申领三个不同产品的试用装。

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Multi-kinase-IN-5 相关抗体

Top Publications Citing Use of Products

查看 FGFR 亚型特异性产品:

查看所有亚型
FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 PDGFR 亚型特异性产品:

查看所有亚型
PDGFR PDGFRβ PDGFRα

查看 Raf 亚型特异性产品:

查看所有亚型
BRaf c-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively[1].

IC50 & Target

FGFR1

1.287 μM (IC50)

VEGFR1

 

VEGFR2

 

Braf

 

PDGFR

 

体外研究
(In Vitro)

Multi-kinase-IN-5 (compound 15c) 对国家癌症研究所 (NCI) 60 种细胞系中的大多数细胞表现出积极的抗增殖活性，平均生长抑制率为 61.83%，针对 MCT-7、DU 145 和 HCT-116 细胞系 的 IC50 值分别为 4.39、1.06 和 0.34 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-kinase-IN-5 相关抗体:
分子量

377.42

Formula

C19H15N5O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-5RETFGFRVEGFRc-Kitc-Met/HGFRPDGFRRafFibroblast growth factor receptorVascular endothelial growth factor receptorSCFRCD117Platelet-derived growth factor receptorRaf kinasesMCT-7DU 145HCT-116Inhibitorinhibitorinhibit

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