2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Muraglitazar

Muraglitazar是一种PPAR α/γ的双激动剂，用于研究 2 型糖尿病及相关血脂异常。Muraglitazar对人PPARα (EC50 = 320 nM)和PPARγ(EC50 = 110 nM)具有较强的体外活性。

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Muraglitazar Chemical Structure

Muraglitazar Chemical Structure

CAS No. : 331741-94-7

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规格 价格 是否有货 数量
1 mg ￥3337
1 - 2 周
5 mg   询价  
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Muraglitazar 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Muraglitazar is a PPAR α/γ dual agonist for the research of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα (EC50 = 320 nM) and PPARγ(EC50 = 110 nM)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.035 μM
Compound: I
Agonist activity at GAL4 tagged human PPARgamma ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at GAL4 tagged human PPARgamma ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 25686852]
HEK293 EC50
0.04 μM
Compound: 1, muraglitazar
Agonist activity at human PPARgamma expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay
Agonist activity at human PPARgamma expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay
[PMID: 18511276]
HEK293 EC50
1.41 μM
Compound: I
Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 25686852]
HEK293 EC50
1.41 μM
Compound: 1, muraglitazar
Agonist activity at human PPARalpha expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay
Agonist activity at human PPARalpha expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay
[PMID: 18511276]
Clinical Trial
分子量

516.54

Formula

C29H28N2O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Muraglitazar 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muraglitazar331741-94-7BMS-298585BMS298585BMS 298585PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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产品名称：
Muraglitazar
目录号：
HY-17445
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