2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Mitochondrial Metabolism Antibiotic
  4. Myxothiazol

Myxothiazol 是一种抗真菌抗生素，是线粒体电子传递链复合体 Ⅲ (complex III or bc1 complex) 抑制剂。Myxothiazol 在0.01~3 μg/ml 浓度范围内可抑制许多酵母菌和真菌的生长。

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Myxothiazol Chemical Structure

Myxothiazol Chemical Structure

CAS No. : 76706-55-3

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1 mg ￥4200
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Myxothiazol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2].

体外研究
(In Vitro)

Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[2].
? Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Myxothiazol 相关抗体:
体内研究
(In Vivo)

Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/J6 mice[3]
Dosage: 0.56 mg/kg
Administration: I.p.; 24 hours intervals for at most 4 times
Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
分子量

487.68

Formula

C25H33N3O3S2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Myxococcus fulvus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

Chloroform 中的溶解度 : 10 mg/mL (20.51 mM; 超声加热助溶)

Chloroform 中的溶解度 : 10 mg/mL (20.51 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0505 mL 10.2526 mL 20.5052 mL
5 mM 0.4101 mL 2.0505 mL 4.1010 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.53%

COA (283 KB)

产品使用指南 (1538 KB)
参考文献

Myxothiazol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Chloroform / Chloroform 1 mM 2.0505 mL 10.2526 mL 20.5052 mL 51.2631 mL
5 mM 0.4101 mL 2.0505 mL 4.1010 mL 10.2526 mL
10 mM 0.2051 mL 1.0253 mL 2.0505 mL 5.1263 mL
15 mM 0.1367 mL 0.6835 mL 1.3670 mL 3.4175 mL
20 mM 0.1025 mL 0.5126 mL 1.0253 mL 2.5632 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myxothiazol76706-55-3FungalMitochondrial MetabolismAntibioticfungimitochondrialelectrontransportchainrespiratorytoxicityInhibitorinhibitorinhibit

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目录号：
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