2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. nAChR agonist CMPI hydrochloride

nAChR agonist CMPI hydrochloride 

目录号: HY-136258
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nAChR agonist CMPI hydrochloride 是一种有效和选择性的 nAChR (包含一个 α4:α4 亚基界面) 的正变构调节剂 (PAM)。nAChR agonist CMPI hydrochloride 可增强 (α4)3(β2)2 nAChR 对 Ach (10 µM) 的响应，EC50 值为 0.26 µM。nAChR agonist CMPI hydrochloride 具有研究尼古丁依赖性和许多与降低脑胆碱能活性有关的神经疾病的潜力。

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nAChR agonist CMPI hydrochloride Chemical Structure

nAChR agonist CMPI hydrochloride Chemical Structure

CAS No. : 2250025-94-4

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nAChR agonist CMPI hydrochloride 相关抗体

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生物活性

nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity[1][2].

IC50 & Target

nAChR[1]
体外研究
(In Vitro)

CMPI (0.01-10 µM) potentiates (α4)3(β2)2 (low ACh sensitivity) but not (α4)2(β2)3 (high ACh sensitivity) nAChRs in Xenopus laevis oocytes[1].
CMPI (0.01-10 µM) inhibits (α4)2(β2)3, human muscle and Torpedo nAChRs with IC50s of 0.6, 0.7 and 0.2 µM, respectively in Xenopus oocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

nAChR agonist CMPI hydrochloride 相关抗体:
分子量

379.28

Formula

C18H20Cl2N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

nAChR agonist CMPI hydrochloride 相关分类

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Keywords:

nAChR agonist CMPI2250025-94-4nAChRNicotinic acetylcholine receptorsα4:α4(α4)3(β2)2nicotineneuropsychiatricInhibitorinhibitorinhibit

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