2. 天然产物
  3. 植物 萜类
  4. 败酱科 倍半萜
  5. 甘松
  6. Narchinol B

Narchinol B (Compound 4) 是一种倍半萜类化合物。Narchinol B 具有抗炎作用。Narchinol B通过抑制促炎介质（包括前列腺素 E2 (PGE2)、诱导型一氧化氮合酶 (iNOS) 和环氧合酶-2 (COX-2) 蛋白）以及促炎细胞因子（如白细胞介素 (IL)-1b、IL-6 和肿瘤坏死因子-α (TNF-α) 的产生而表现出抗神经炎症作用。Narchinol B 显著抑制 LPS 诱导的 BV2 细胞中 NO 的过量产生 (IC50=2.43 μM) 。

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Narchinol B Chemical Structure

Narchinol B Chemical Structure

CAS No. : 1356822-09-7

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Narchinol B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC50=2.43 μM) [1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-2 IC50
1.7 μM
Compound: 4
Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
[PMID: 29221883]
BV-2 IC50
1.73 μM
Compound: 4
Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
[PMID: 29221883]
BV-2 IC50
2.38 μM
Compound: 4
Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
[PMID: 29221883]
BV-2 IC50
2.43 μM
Compound: 4
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA
[PMID: 29221883]
BV-2 IC50
2.9 μM
Compound: 4
Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
[PMID: 29221883]
Microglia IC50
3.1 μM
Compound: 4
Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs
[PMID: 29221883]
Microglia IC50
3.11 μM
Compound: 4
Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
[PMID: 29221883]
Microglia IC50
4 μM
Compound: 4
Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
[PMID: 29221883]
Microglia IC50
4.17 μM
Compound: 4
Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA
Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA
[PMID: 29221883]
Microglia IC50
9.83 μM
Compound: 4
Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA
[PMID: 29221883]
RAW264.7 IC50
4.6 μM
Compound: 8
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 22079762]
分子量

208.25

Formula

C12H16O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Narchinol B 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Narchinol B1356822-09-7OthersSesquiterpenoidsprimary microglial cellsBV2 microglial cellsanti-neuroinflammationInhibitorinhibitorinhibit

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