2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Nav1.7-IN-15

Nav1.7-IN-15 (Compd 9) 是有效的 Nav1.7 拮抗剂，其对 hNav1.7 PX 的 IC50 值为0.42 μM。

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Nav1.7-IN-15 Chemical Structure

Nav1.7-IN-15 Chemical Structure

CAS No. : 1356834-62-2

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Nav1.7-IN-15 相关抗体

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查看 Sodium Channel 亚型特异性产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nav1.7-IN-15 (Compd 9) is a potent and state-dependent Nav1.7 antagonist, with an IC50 of 0.42 μM for hNav1.7 PX[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.08 μM
Compound: 9
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
[PMID: 22209205]
HEK293 IC50
0.2 μM
Compound: 9
Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay
Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay
[PMID: 22209205]
HEK293 IC50
0.42 μM
Compound: 9
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay
[PMID: 22209205]
HEK293 IC50
0.5 μM
Compound: 9
Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
[PMID: 22209205]
分子量

303.42

Formula

C16H21N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nav1.7-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.7-IN-151356834-62-2Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-138816
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