2. Anti-infection
  3. Antibiotic Orthopoxvirus
  4. Neplanocin A

Neplanocin A  (Synonyms: (-)-Neplanocin A)

目录号: HY-130430
产品使用指南

摩尔计算器

Neplanocin A ((-)-Neplanocin A) 是一种抗肿瘤抗生素 (antibiotic)，对小鼠 L1210 白血病具有显著的抗肿瘤活性。Neplanocin A 也是一种不可逆的 AdoHcy hydrolase 抑制剂 (Ki=8.39 nM)。Neplanocin A 还具有抗病毒活性，能有效抑制 vaccinia 病毒。Neplanocin A 可从 Ampullariella regularis 中获得。

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Neplanocin A Chemical Structure

Neplanocin A Chemical Structure

CAS No. : 72877-50-0

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规格 价格 是否有货
500 μg ￥6930
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Neplanocin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis[1].

IC50 & Target

AdoHcy hydrolase; vaccinia[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.22 μM
Compound: 1
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
A549 IC50
2.16 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
HCT-116 IC50
0.9 μM
Compound: 1
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
HCT-116 IC50
1.45 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
MDA-MB-231 IC50
0.4 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
MDA-MB-231 IC50
0.86 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
PC-3 IC50
2.14 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
PC-3 IC50
3.7 μM
Compound: 1
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
SH-SY5Y IC50
10 nM
Compound: 8, NepA
Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis
Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis
[PMID: 24813734]
SK-HEP1 IC50
2.36 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human SKHEP1 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human SKHEP1 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
SK-HEP1 IC50
4.5 μM
Compound: 1
Cytotoxicity against human SKHEP1 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human SKHEP1 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
SNU-638 IC50
0.7 μM
Compound: 1
Cytotoxicity against human SNU638 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
Cytotoxicity against human SNU638 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay
[PMID: 26010585]
SNU-638 IC50
0.82 μM
Compound: Neplanocin A; 1a
Cytotoxicity against human SNU638 cells assessed as decrease in cell viability after 72 hrs by SRB assay
Cytotoxicity against human SNU638 cells assessed as decrease in cell viability after 72 hrs by SRB assay
[PMID: 29906687]
Vero IC50
0.26 μg/mL
Compound: 1 (NPA)
Cytotoxic effect on host cells during growth phase of virus in vero cell cultures using MTT method
Cytotoxic effect on host cells during growth phase of virus in vero cell cultures using MTT method
10.1016/S0960-894X(01)80163-3
Vero IC50
152 μg/mL
Compound: 1 (NPA)
Cytotoxic effect on host cells during stationary phase of virus in vero cell cultures using MTT method
Cytotoxic effect on host cells during stationary phase of virus in vero cell cultures using MTT method
10.1016/S0960-894X(01)80163-3
Vero IC50
155 μg/mL
Compound: 1a (NPA)
Cytotoxic concentration required to reduce the number of Vero cells by 50%
Cytotoxic concentration required to reduce the number of Vero cells by 50%
[PMID: 8809173]
体外研究
(In Vitro)

Neplanocin A (1 μM; 0-70 h) 抑制小鼠 L929 细胞的生长[1]。
Neplanocin A (1 μM; 72 h) 抑制小鼠 L929 细胞单层培养物中牛痘病毒空斑的形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neplanocin A 相关抗体:

Cell Viability Assay[1]

Cell Line: L929 mouse cells
Concentration: 1 μM
Incubation Time: 0-70 h
Result: Slowed the rate of increase in cell number.
分子量

263.25

Formula

C11H13N5O3
CAS 号
结构分类
初始来源

Ampullariella regular
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neplanocin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neplanocin A72877-50-0(-)-Neplanocin AAntibioticOrthopoxvirusvacciniaAmpullariella regulariscancertumorvirusleukemiaInhibitorinhibitorinhibit

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