Nipradolol  (Synonyms: KT 210; K 351; Hypadil)

Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery^[1][2].

Nipradolol (1 μM; 10 分钟) 抑制钾诱导的犬肌肉收缩，ID₅₀ 值为 0.8 μM^[1]。
Nipradolol (1 μM; 10 分钟) 降低静息张力，抑制近端区钠诱导的收缩^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nipradolol (0.125%, 0.25%, 0.5%; 静脉注射; 单剂量) 以浓度依赖的方式抑制兔眼眼压的增加^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

326.34

C₁₅H₂₂N₂O₆

81486-22-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyran (K-351) and its denitrated derivative on smooth muscle cells of the dog coronary artery. Br J Pharmacol. 1983 May;79(1):285-95.  [Content Brief]

  [2]. Nishio K. Alpha-1-adrenoceptor blocking activity of KT-210 (nipradilol ophthalmic solution) on intraocular pressure in the rabbit eye[J]. Nihon Ganka Kiyo (Folia Ophthalmol Jpn), 1999, 50: 655-660.