2. Epigenetics
  3. Histone Methyltransferase
  4. [Nle20] H4 peptide (16−23)

[Nle20] H4 peptide (16−23) 是一种对组蛋白甲基转移酶 SETD8 具有强烈抑制活性的多肽 (Kd=0.14 μM)，通过与 SETD8 的底物结合位点竞争，从而抑制了 SETD8 对组蛋白 H4 的甲基化作用。[Nle20] H4 peptide (16−23) 可作为抗癌疗法的先导化合物。

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[Nle20] H4 peptide (16−23) Chemical Structure

[Nle20] H4 peptide (16−23) Chemical Structure

CAS No. : 2042178-19-6

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[Nle20] H4 peptide (16−23) 相关抗体

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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生物活性

[Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (Kd=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy[1].

分子量

1077.33

Formula

C47H88N20O9
CAS 号
Sequence

Lys-Arg-His-Arg-{Nle}-Val-Leu-Arg
Sequence Shortening

KRHR-{Nle}-VLR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

[Nle20] H4 peptide (16−23) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Nle20] H4 peptide (16−23)2042178-19-6Histone MethyltransferasePeptidesinhibitorhistone H4cancerSETD8Inhibitorinhibit

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