2. Others Apoptosis Neuronal Signaling GPCR/G Protein
  3. Isotope-Labeled Compounds Apoptosis Opioid Receptor
  4. Noscapine-13C,d3

Noscapine-13C,d3是氘代标记的Noscapine。Noscapine ((S,R)-Noscapine) 是一种具有口服活性的苯酞异喹啉生物碱，具有强效镇咳作用。Noscapine 通过激活 sigma 阿片类受体 (sigma opioid receptors) 发挥镇咳作用，是一种非竞争性 Bradykinin 抑制剂。Noscapine 破坏微管动力学，诱导细胞有丝分裂停滞和凋亡 (apoptosis) 以及活性。Noscapine 具有抗癌，神经保护，抗炎活性，并且可以穿越血脑屏障。

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Noscapine-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Noscapine-13C,d3 Chemical Structure

CAS No. : 1217680-57-3

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Other Forms of Noscapine-13C,d3:

Noscapine-13C,d3 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Noscapine-13C,d3 is a deuterated labeled Noscapine[1]. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier[2][3][4][5][6].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Noscapine-13C,d3 相关抗体:
体内研究
(In Vivo)

Noscapine (300?mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

417.43

Formula

C2113CH20D3NO7
CAS 号
非标记 CAS

128-62-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Noscapine-13C,d3 相关分类

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Keywords:

Noscapine-13C,d31217680-57-3Isotope-Labeled CompoundsApoptosisOpioid ReceptorInhibitorinhibitorinhibit

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