2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. NSC81111

NSC81111 是一种有效且具有口服活性的 EGFR-TK 抑制剂，IC50 为 0.15 nM。NSC81111 具有抗癌作用。

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NSC81111 Chemical Structure

NSC81111 Chemical Structure

CAS No. : 1678-14-4

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NSC81111 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1].

IC50 & Target

IC50: 0.15 nM (EGFR-TK)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
3.81 μM
Compound: NSC81111
Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay
Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay
[PMID: 34995690]
HeLa IC50
8.12 μM
Compound: NSC81111
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition by MTT assay
[PMID: 34995690]
分子量

308.33

Formula

C19H16O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC81111 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC811111678-14-4NSC 81111NSC-81111EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-144441
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