2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. NUCC-390

NUCC-390 是新型的选择性小分子 CXCR4 receptor 受体激动剂。NUCC-390 可以诱导 CXCR4 受体的内化，作用方式与 AMD3100 (HY-10046) 相反。NUCC-390 在动物模型中，有助于神经退行性变后神经功能恢复。

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NUCC-390 Chemical Structure

NUCC-390 Chemical Structure

CAS No. : 1060524-97-1

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Other Forms of NUCC-390:

NUCC-390 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046)[1][2]. NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo[2].

IC50 & Target[1]

CXCR4

 

体外研究
(In Vitro)

NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1].
NUCC-390 (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1].
NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1].
NUCC-390 (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NUCC-390 相关抗体:

Western Blot Analysis[1]

Cell Line: C8161 cells 
Concentration: 10 μM
Incubation Time: Pre-treated 30 mins
Result: Increased the level of pERK.

Cell Proliferation Assay[2]

Cell Line: Cerebellar granule neurons (CGNs)
Concentration: 0 μM; 0.0625 μM; 0.25 μM; 1.25 μM
Incubation Time: 24 hours
Result: Stimulated axonal growth via CXCR4.
体内研究
(In Vivo)

NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six to eight-week-old CD1 mice[2]
Dosage: 3.2 mg/kg
Administration: Hind limb injection; twice daily; 3 days
Result: Promoted functional and anatomical recovery of the NMJ.
分子量

395.54

Formula

C23H33N5O
CAS 号
性状

固体

颜色

Light brown to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

NUCC-390 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NUCC-3901060524-97-1NUCC390NUCC 390CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR4internalization(Ca)i responseC8161HEK293neurodegenerationneuroregenerationneuromuscular junctionmotorCGNsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-111793
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