Obrindatamab  (Synonyms: MGD009)

Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer^[1].

scFv-h-CH2-CH3(_scFv)_h-CH2-CH3

Chimeric; Humanized

MGD009 (MGD009) 结合人和食蟹猴 CD3 和 B7-H3，对人 CD3ε/δ、食蟹猴 CD3ε/δ、人 B7-H3-His 和食蟹猴 B7-H3-His 的 K_D 值分别为 13.9、14.7、24.6 和 30.2 nM^[1]。
Obrindatamab (0.01-1000 ng/mL; A498, U87, 22Rv1, 和 Detroit562 细胞) 介导多种 B7-H3 表达肿瘤细胞系的重定向杀伤^[1]。
Obrindatamab (0.01-1000 ng/mL；PBMC 和 A498 细胞) 介导的 T 细胞活化和增殖具有靶抗原依赖性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Obrindatamab (MGD009; 0.004-1 mg/kg; i.v.) 抑制人 T 细胞或 PBMC 重建小鼠中表达 B7-H3 的肿瘤异种移植物的生长和肿瘤消退^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2069959-72-2

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  scFv-h-CH2-CH3(_scFv)_h-CH2-CH3

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  Immobilized Obrindatamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC₅₀ for this effect is 0.543 ng/mL.
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  Immobilized Obrindatamab can bind Human B7-H3 Protein (ECD, His Tag). The EC₅₀ for this effect is 3.27 ng/mL.

• [1]. Paul M, et, al. MGD009, a B7-H3 x CD3 Bispecific Dual-Affinity Re-Targeting (DART®) Molecule Directing T Cells to Solid Tumors.