2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Ochnaflavone

Ochnaflavone 是一种 IIA 型分泌磷脂酶A2 (sPLA2-IIA) 的抑制剂，IC50 为 3.45 µM。 Ochnaflavone 具有显著的抗炎和保护肝脏作用，可抑制碳四氯化物 (CCl4) 诱导的大鼠肝脏磷脂酰乙醇胺 (PE) 的降解及脂质过氧化,对脂质过氧化的 IC50 为 7.16 µM。Ochnaflavone 可用于研究肝脏损伤以及炎症性疾病。

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Ochnaflavone Chemical Structure

Ochnaflavone Chemical Structure

CAS No. : 50276-96-5

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Ochnaflavone 相关抗体

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Phospholipase A PLD Phospholipase C

  • 生物活性

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生物活性

Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC50 of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC50 of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases[1].

IC50 & Target

sPLA2

3.45 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
54.5 μM
Compound: 3
Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay
[PMID: 34875389]
分子量

538.46

Formula

C30H18O10
CAS 号
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ochnaflavone 相关分类

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Keywords:

Ochnaflavone50276-96-5PhospholipaseAnti-inflammatoryLiver-protectiveInhibitorinhibitorinhibit

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