Omeprazole-d₃ sodium  (Synonyms: 奥美拉唑钠盐-d₃; H 16868-d₃ sodium)

Omeprazole-d₃ sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM^[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria^[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)^[3].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Omeprazole (H 16868) 是一种质子泵抑制剂，用于处理消化不良、消化性溃疡病、胃食管反流病、喉咽反流和 Zollinger-Ellison 综合征。可能 Omeprazole 抑制胃酸分泌，Omeprazole 是一种酸不稳定化合物^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

370.42

C₁₇H₁₅D₃N₃NaO₃S

73590-58-6

奥美拉唑钠盐-d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.  [Content Brief]

  [3]. Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.  [Content Brief]

  [4]. Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.  [Content Brief]