2. Membrane Transporter/Ion Channel Apoptosis
  3. P-glycoprotein Apoptosis
  4. P-gp inhibitor 22

P-gp inhibitor 22 是一种 P-糖蛋白（P-gp）抑制剂，可有效抑制 P-pg 和外排功能。P-gp inhibitor 22 诱导 MCF-7/ADR 细胞凋亡 (apoptosis) 以及 S 期的积累。

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P-gp inhibitor 22 Chemical Structure

P-gp inhibitor 22 Chemical Structure

CAS No. : 1226674-74-3

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P-gp inhibitor 22 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase[1].

体外研究
(In Vitro)

P-gp inhibitor 22（compound 4b；6.25-100 μM；24 小时）对 MCF-7/ADR 细胞具有显着的活性[1]。
P-gp inhibitor 22（compound 4b；5 μM；24 小时）可诱导 MCF-7/ADR 细胞凋亡，并在 S 期积累[1]。
P-gp inhibitor 22 抑制多种细胞系，如 PC-3、SKOV-3、HeLa、MCF-7/ADR、HFL-1 和 WI-38 细胞，IC50 值分别为 3.3 μM、0.7 μM、2.4 μM、5.0 μM、72.0 μM 和 61.1 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

P-gp inhibitor 22 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7/ADR cells
Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
Incubation Time: 24 h
Result: Showed dose-dependent cytotoxicity in MCF-7/ADR cells.

Cell Cycle Analysis[1]

Cell Line: MCF-7/ADR cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Showed cell cycle arrest at S phase and induced apoptosis.
分子量

348.78

Formula

C20H13ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P-gp inhibitor 22 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp inhibitor 221226674-74-3P-glycoproteinApoptosisP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243P-glycoprotein inhibitorefflux functionapoptosisS phaseInhibitorinhibitorinhibit

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