2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. PAR4 antagonist 7

PAR4 antagonist 7 (Compound 20f) 是选择性 PAR4 拮抗剂 (IC50: 1.72 nM)。PAR4 antagonist 7 可抑制 PAR4 激动剂诱导的血小板聚集。PAR4 antagonist 7 具有良好的代谢稳定性。PAR4 antagonist 7 在小鼠中没有表现出出血倾向。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAR4 antagonist 7 Chemical Structure

PAR4 antagonist 7 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PAR4 antagonist 7 相关抗体

Top Publications Citing Use of Products

查看 Protease Activated Receptor (PAR) 亚型特异性产品:

查看所有亚型
PAR1 PAR2 PAR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAR4 antagonist 7 (Compound 20f) is selective PAR4 antagonist (IC50: 1.72 nM). PAR4 antagonist 7 inhibits PAR4 agonist-induced platelet aggregation. PAR4 antagonist 7 has good metabolic stability. PAR4 antagonist 7 does not show a bleeding tendency in mice[1].

体外研究
(In Vitro)

PAR4 antagonist 7 抑制 PAR4 激动剂肽 (PAR4-AP) (75 μM) 诱导的洗涤血小板 (WP) 聚集，IC50 为 15.32 nM[1]。
PAR4 antagonist 7 抑制 PAR4-AP (75 μM) 诱导的人富含血小板的血浆 (PRP) 水平，IC50 为 6.39 nM[1]。
PAR4 antagonist 7 还抑制 AYPGKF-NH2 (75 μM) 或凝血酶 (0.1 U/mL) 诱导的人类 PRP 血小板聚集，并且不影响 SFLLRN-NH2 (5 μM)、胶原蛋白 (10 mg/mL)、ADP (10 μM) 或U46619 (HY-108566) (3 μM) 诱导血小板聚集[1]。
PAR4 antagonist 7 在人肝微粒体中表现出优异的代谢稳定性 (T1/2 = 249.83 分钟)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAR4 antagonist 7 相关抗体:
体内研究
(In Vivo)

PAR4 antagonist 7 (2.5-10 mg/kg，灌胃) 在小鼠中没有表现出出血倾向，有解决出血风险的潜力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

541.55

Formula

C28H20FN5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAR4 antagonist 7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAR4 antagonist 7Protease Activated Receptor (PAR)Thrombin receptorsplatelet aggregationCoronary artery diseaseantiplateletBleeding riskInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PAR4 antagonist 7
目录号：
HY-159895
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z