2. Neuronal Signaling Protein Tyrosine Kinase/RTK Immunology/Inflammation JAK/STAT Signaling Apoptosis
  3. Trk Receptor IRAK Pim Apoptosis
  4. PC-046

PC-046 是一种多靶点抑制剂，针对酪氨酸受体激酶 B (TrkB)、IRAK-4 和 Pim-1，IC50 分别为 13.4 μM、15.4 μM 和 19.1 μM。PC-046 对胰腺癌细胞 BxPC3 具有细胞毒性，IC50 在 7.5-130 nM 之间。PC-046 诱导 BxPC3 细胞凋亡 (apoptosis)，并在 G2/M 期阻滞细胞周期。PC-046 具有抗肿瘤作用，在小鼠体内具有良好的药代动力学特征。

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PC-046 Chemical Structure

PC-046 Chemical Structure

CAS No. : 1202401-59-9

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PC-046 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

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TrkA TrkB TrkC Trk

查看 IRAK 亚型特异性产品:

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IRAK1 IRAK4

查看 Pim 亚型特异性产品:

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PIM1 PIM2 PIM3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice[1].

IC50 & Target

IC50: 13.4 μM (TrkB); 15.4 μM (IRAK-4); 19.1 μM (Pim-1)
分子量

358.39

Formula

C22H18N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PC-046 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PC-0461202401-59-9PC046PC 046Trk ReceptorIRAKPimApoptosisTropomyosin related kinase receptor Interleukin-1 receptor associated kinaseIL-1R associated kinasePim kinasesSCID mousePC3MiaPaCa-2multi-targetpancreatic cancerInhibitorinhibitorinhibit

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