2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-41

PD-1/PD-L1-IN-41 (Compound 5c) 是一种 PD-L1 和 PD-1 的抑制剂，IC50 值为 10.2 nM。

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PD-1/PD-L1-IN-41 Chemical Structure

PD-1/PD-L1-IN-41 Chemical Structure

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PD-1/PD-L1-IN-41 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/ PD-L1-in-41 (Compound 5c) is a PD-L1 and PD-1 inhibitor with IC50 value of 10.2 nM[1].

IC50 & Target

IC50: 10.2 nM (PD-1/PD-L1)[1]
体外研究
(In Vitro)

PD-1/PD-L1-IN-41 (Compound 5c) (100 μl; 24小时) 对 CHO-hPD-L1 细胞的 EC50 为 11.6 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1/PD-L1-IN-41 相关抗体:
体内研究
(In Vivo)

PD-1/PD-L1-IN-41 (Compound 5c) 也可以进行碳-11 的放射性标记，[11C]5c 对 PD-1 阴性和表达 PD-1 的异种移植的 NSG 小鼠都没有特异性结合。这可能归因于放射性示踪剂的快速代谢，血浆蛋白结合引起的组织渗透受限，或非特异性或脱靶相互作用水平升高[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.08

Formula

C33H32ClN3O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1/PD-L1-IN-41 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-41PD-1/PD-L1PD-1/Programmed death-ligand 1Carbon-11 radiolabelingNSG mouseCHO and CHO-hPD-L1Inhibitorinhibitorinhibit

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产品名称：
PD-1/PD-L1-IN-41
目录号：
HY-162343
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