2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. PD-1/PD-L1 STAT
  4. PD-L1-IN-6

PD-L1-IN-6 (Compound 16) 通过靶向 STAT3 (KD 为 90.5 nmol/L)，抑制 PD-L1 在中性粒细胞中的表达。PD-L1-IN-6 促进中性粒细胞介导的抗真菌免疫反应。PD-L1-IN-6 具有口服有效性。

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PD-L1-IN-6 Chemical Structure

PD-L1-IN-6 Chemical Structure

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PD-L1-IN-6 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-L1-IN-6 (Compound 16) is an orally active inhibitor for PD-L1 expression in neutrophil by targeting STAT3 with KD of 90.5 nmol/L. PD-L1-IN-6 promotes neutrophil-mediated antifungal immunoresponse[1].

体外研究
(In Vitro)

PD-L1-IN-6 (40 μM) 在 40 μM 时可抑制 80.17% PD-L1 表达，且对中性粒细胞无明显细胞毒性[1]。
PD-L1-IN-6 对血脑屏障具有微透性，pe为1.22×10-6 cm/s[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-L1-IN-6 相关抗体:

Cell Viability Assay[1]

Cell Line: Murine neutrophil
Concentration: 40 μM
Incubation Time:
Result: Maintained 81.52% cell viability at 40 μM.
体内研究
(In Vivo)

PD-L1-IN-6 (50-100 mg/kg,，口服，3 天) 在 C. albicans 感染的C57BL/6 小鼠模型中，抑制 β-葡聚糖诱导的 CXCL1 和 CXCL2 分泌，诱导中性粒细胞迁移，增强中性粒细胞介导的抗真菌免疫[1]。

PD-L1-IN-6 在 SD 大鼠体内的药代动力学分析[1]

route Dose (mg/kg) Cmax (ng/mL) T1/2 (h) Tmax (h) AUC0-t (ng·h/mL) AUC0-inf (ng·h/mL) CL (mL/min/kg) MRT0-t (h) Vss (L/kg) F (%)
po 10 113.52 1.46 0.33 166.57 182.25 - 1.74 - 45.1
iv 2 174.78 0.17 0.14 73.87 75.44 453.10 0.25 7.46 -

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C. albicans infected C57BL/6 mice[1]
Dosage: 50-100 mg/kg
Administration: p.o. for 3 days
Result: Inhibited secretion of CXCL1 and CXCL2, and accumulation of neutrophils in bone marrow.
Caused reduced fungal burden and increased infiltrationn rate of neutrophils in kidney.
分子量

475.38

Formula

C21H24Cl2O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-L1-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-L1-IN-6PD-1/PD-L1STATPD-1/Programmed death-ligand 1Sprague-Dawley ratsC57BL/6 miceInhibitorinhibitorinhibit

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