Pentosan Polysulfate (Sodium) (W/W 43%) 

Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis^[1][2][3].

Pentosan PolysμLfate Sodium 已显示可抑制 HIV-1 活性，在 MT-4 细胞中的 ED₅₀ 为 0.19 μg/mL。它在 0.02 μg/mL 的 ED₅₀ 下抑制 HUT-78 细胞中的 HIV-1 抗原表达，在 4.0 μg/mL 的浓度下获得 HIV-1 抗原表达的完全抑制^[2]。
Pentosan PolysμLfate Sodium 抑制 NF-κB，降低 TNFα 的促炎作用，并降低高糖和晚期糖基化终产物 (AGEs) 刺激的 MCP-1 产生^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pentosan PolysμLfate Sodium 已显示可减少 5/6 肾切除大鼠的间质性炎症和肾小球硬化。Pentosan PolysμLfate Sodium 处理可保护肾功能，显著减少白蛋白尿，并显著降低肾损伤的严重程度，包括肾小管间质炎症。Pentosan PolysμLfate Sodium 还可降低衰老糖尿病肾脏中 TNFα 和促炎基因的上调^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4000-6000

140207-93-8

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Schuchman EH, et al. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013;8(1):e54459.  [Content Brief]

  [2]. Baba M, et al. Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Antiviral Res. 1988 Sep;9(6):335-43.  [Content Brief]

  [3]. Wu J, et al. Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest. 2011 Oct;91(10):1459-71.  [Content Brief]