2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. PF-00956980

PF-00956980 是一种可逆的 pan-JAK 抑制剂，作用于 JAK1、JAK2 和 JAK3 的 IC50 值分别是 2.2、23.1 和 59.9 μM，可用于肺部和皮肤炎症性疾病研究。

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PF-00956980 Chemical Structure

PF-00956980 Chemical Structure

CAS No. : 1262832-74-5

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PF-00956980 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases[1].

IC50 & Target[1]

JAK1

2.2 μM (IC50)

JAK2

23.1 μM (IC50)

JAK3

59.9 μM (IC50)

体内研究
(In Vivo)

The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog

Spesies Dose (mg/kg) Cl (mL/min/Kg) Clunbound (mL/min/Kg) Vss (L/Kg) Terminal T1/2 (h) Oral Bioavailability
Rat i.v. 0.5 48 >48,000 0.8 2.1 -
Rat p.o. 1 - - - - <5%
Dog i.v. 0.1 18 >18,000 1.0 2.0 -

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

342.44

Formula

C18H26N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-00956980 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-009569801262832-74-5PF00956980PF 00956980JAKJanus kinaseJAK1JAK2JAK3lungskin inflammatoryInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-108342
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