2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GlyT
  4. PF-03463275 hydrochloride

PF-03463275 hydrochloride 是一种中枢神经系统渗透性、具有口服活性、选择性、竞争性甘氨酸转运蛋白-1 (GlyT1) 可逆抑制剂，Ki 为 11.6 nM。PF-03463275 hydrochloride 有可能用于精神分裂症的研究。

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PF-03463275 hydrochloride Chemical Structure

PF-03463275 hydrochloride Chemical Structure

CAS No. : 1173177-11-1

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PF-03463275 hydrochloride 的其他形式现货产品:

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Other Forms of PF-03463275 hydrochloride:

PF-03463275 hydrochloride 相关抗体

Top Publications Citing Use of Products

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GlyT1 GlyT2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-03463275 hydrochloride is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 hydrochloride has the potential for Schizophrenia research[1][2].

IC50 & Target

GLT1

116 nM (Ki)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
8500 nM
Compound: 10
Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method
Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method
[PMID: 19410451]
分子量

449.78

Formula

C19H24Cl3FN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-03463275 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-034632751173177-11-1PF03463275PF 03463275GlyTGlycine transportersGlyT1InhibitorschizophreniaoralCNSinhibitorinhibit

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产品名称：
PF-03463275 hydrochloride
目录号：
HY-10716
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