2. Others Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Biochemical Assay Reagents EGFR
  4. PF-06672131

PF-06672131 是一种炔基化阿法替尼衍生物和对半胱氨酸具有反应活性的小分子探针。PF-06672131 是表皮生长因子受体 (EGFR) 激酶的抑制剂，可靶向 EGFR 的 ATP 结合口袋。PF-06672131 可用于基于活性的蛋白质谱分析研究。

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PF-06672131 Chemical Structure

PF-06672131 Chemical Structure

CAS No. : 1621002-27-4

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PF-06672131 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-06672131 is an alkynylated afatinib derivative and a small molecule probe that is reactive to cysteine. PF-06672131 is an inhibitor of epidermal growth factor receptor (EGFR) kinase that targets the ATP pockets of EGFR. PF-06672131 can be used for activity-based protein profiling studies[1].

分子量

453.90

Formula

C23H21ClFN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-06672131 相关分类

  • 摩尔计算器

  • 稀释计算器

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-066721311621002-27-4PF06672131PF 06672131Biochemical Assay ReagentsEGFREpidermal growth factor receptorErbB-1HER1alkynylated afatinibInhibitorinhibitorinhibit

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产品名称：
PF-06672131
目录号：
HY-138916
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