2. Immunology/Inflammation
  3. PGE synthase
  4. PF-9184

PF-9184 是一种有效且高度选择性的人微粒体前列腺素 E 合酶 1 (mPGES-1) 的抑制剂，IC50 值为 16.5 nM。PF-9184 体外抑制 IL-1β 诱导的 PGE2 合成。

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PF-9184 Chemical Structure

PF-9184 Chemical Structure

CAS No. : 1221971-47-6

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规格 价格 是否有货 数量
1 mg ￥485
In-stock
5 mg ￥1073
In-stock
10 mg ￥1650
In-stock
25 mg ￥2825
In-stock
50 mg ￥4063
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

PF-9184 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-9184 is a potent and highly selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), with an IC50 of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro[1].

IC50 & Target

IC50: 16.5 nM (mPGES-1)[1]
体外研究
(In Vitro)

PF-9184 (0.015-100 μM; 24 hours) inhibits IL-1β-stimulated prostaglandin E2 (PGE2) synthesis in rheumatoid arthritis (RASF) in synovial fibroblasts derived from patients and has no apparent cytotoxic effects up to 100 μM[1].
PF-9184 (0.015-100 μM) potently blocks mPGES-1 ability to synthesize PGE2 from PGH2, and with no apparent inhibitory effects on COX-2 and prostacyclin synthase in cells[1].
PF-9184 (0.015-100 μM) inhibits PGE2 weakly but has no effect on TXB2 synthesis except at 100 μM in human whole blood and modified blood assays[1].
PF-9184 is a poor inhibitor of recombinant rat mPGES-1 (IC50=1080±398 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PF-9184 相关抗体:
体内研究
(In Vivo)

PF-9184 (oral administration or even local delivery) has no effect on PGE2 synthesis in recombinant rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

461.32

Formula

C21H14Cl2N2O4S
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (216.77 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1677 mL 10.8385 mL 21.6769 mL
5 mM 0.4335 mL 2.1677 mL 4.3354 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

PF-9184 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1677 mL 10.8385 mL 21.6769 mL 54.1923 mL
5 mM 0.4335 mL 2.1677 mL 4.3354 mL 10.8385 mL
10 mM 0.2168 mL 1.0838 mL 2.1677 mL 5.4192 mL
15 mM 0.1445 mL 0.7226 mL 1.4451 mL 3.6128 mL
20 mM 0.1084 mL 0.5419 mL 1.0838 mL 2.7096 mL
25 mM 0.0867 mL 0.4335 mL 0.8671 mL 2.1677 mL
30 mM 0.0723 mL 0.3613 mL 0.7226 mL 1.8064 mL
40 mM 0.0542 mL 0.2710 mL 0.5419 mL 1.3548 mL
50 mM 0.0434 mL 0.2168 mL 0.4335 mL 1.0838 mL
60 mM 0.0361 mL 0.1806 mL 0.3613 mL 0.9032 mL
80 mM 0.0271 mL 0.1355 mL 0.2710 mL 0.6774 mL
100 mM 0.0217 mL 0.1084 mL 0.2168 mL 0.5419 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-91841221971-47-6PF9184PF 9184PGE synthaseProstaglandin E synthasemicrosomalprostaglandinsynthase-1mPGES-1inflammationosteoarthritisrheumatoidarthritisInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-19622
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