1. Neuronal Signaling
  2. CaMK
  3. Ph-HTBA

Ph-HTBA 是 CaMKIIα 的高亲和力、脑穿透调节剂。Ph-HTBA 对 CaMKIIα 具有结合亲和力,Kd 值为 757 nM。Ph-HTBA 可用于缺血和神经退行性疾病的研究。

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Ph-HTBA Chemical Structure

Ph-HTBA Chemical Structure

CAS No. : 2368927-41-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1].

IC50 & Target

Kd: 757 nM (CaMKIIα)[1]

体外研究
(In Vitro)

Ph-HTBA can inhibit HOCPCA binding with a Ki value of 1.4 μM[1].
Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM[1].
Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

294.34

Formula

C19H18O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Ph-HTBA
目录号:
HY-151797
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