2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Anti-infection Autophagy
  3. Dopamine Receptor Adrenergic Receptor CaMK P-glycoprotein Influenza Virus Autophagy
  4. Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride  (Synonyms: 盐酸三氟拉嗪)

目录号: HY-B0532A 纯度: 99.90%
COA 产品使用指南

摩尔计算器

Trifluoperazine dihydrochloride 是一种抗精神病药物，通过阻断中枢多巴胺受体 (dopamine receptors) 起作用。Trifluoperazine dihydrochloride 是一种有效的 α1-adrenergic 受体拮抗剂。Trifluoperazine dihydrochloride 是一种有效的 NUPR1 抑制剂，具有抗癌活性。Trifluoperazine dihydrochloride是一种钙调蛋白 (calmodulin) 抑制剂，还可抑制 P-糖蛋白 (P-glycoprotein)，可用于精神分裂症的研究。Trifluoperazine dihydrochloride 是流感病毒 (influenza virus) 形态发生的可逆抑制剂。

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Trifluoperazine dihydrochloride Chemical Structure

Trifluoperazine dihydrochloride Chemical Structure

CAS No. : 440-17-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥425
In-stock
50 mg ￥218
In-stock
100 mg ￥300
In-stock
500 mg ￥700
In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Trifluoperazine dihydrochloride:

Trifluoperazine dihydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
KG-1a IC50
4.58 μM
Compound: TFP
Antiproliferative activity against human KG1a cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human KG1a cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
MCF7 IC50
11.33 μM
Compound: TFP
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
MDA-MB-231 IC50
21.58 μM
Compound: TFP
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
NCI-H1650 GI50
12.2 μM
Compound: Trifluoperazine
Cytotoxicity against human NCI-H1650 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human NCI-H1650 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26372073]
Neutrophil IC50
12.2 μM
Compound: TFP
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of beta-glucuronidase release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of beta-glucuronidase release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
[PMID: 12662101]
Neutrophil IC50
13.2 μM
Compound: TFP
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of lysozyme release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of lysozyme release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
[PMID: 12662101]
NSC IC50
10.1 μM
Compound: TFP
Cytotoxicity against human NSC cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human NSC cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29614416]
SK-BR-3 IC50
15.89 μM
Compound: TFP
Antiproliferative activity against human SKBR3 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human SKBR3 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
SUM-159-PT IC50
17.03 μM
Compound: TFP
Antiproliferative activity against human SUM159 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human SUM159 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
U-87MG ATCC EC50
13.5 μM
Compound: TFP
Induction of intracellular Ca2+ level in human U87MG cells by Fura-2 AM dye-based assay
Induction of intracellular Ca2+ level in human U87MG cells by Fura-2 AM dye-based assay
[PMID: 29614416]
U-87MG ATCC IC50
9.9 μM
Compound: TFP
Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29614416]
体外研究
(In Vitro)

Trifluoperazine dihydrochloride is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dihydrochloride has been an extensively studied drug molecule that has been used as a calmodulin inhibitor[3][4].
Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trifluoperazine dihydrochloride 相关抗体:
分子量

480.42

Formula

C21H26Cl2F3N3S
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸三氟拉嗪；甲哌氟丙嗪；三氟吡拉嗪
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (104.08 mM; 超声助溶)

DMSO 中的溶解度 : 50 mg/mL (104.08 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0815 mL 10.4076 mL 20.8151 mL
5 mM 0.4163 mL 2.0815 mL 4.1630 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.20 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.20 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.98%

COA (267 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

Trifluoperazine dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.0815 mL 10.4076 mL 20.8151 mL 52.0378 mL
5 mM 0.4163 mL 2.0815 mL 4.1630 mL 10.4076 mL
10 mM 0.2082 mL 1.0408 mL 2.0815 mL 5.2038 mL
15 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4692 mL
20 mM 0.1041 mL 0.5204 mL 1.0408 mL 2.6019 mL
25 mM 0.0833 mL 0.4163 mL 0.8326 mL 2.0815 mL
30 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
40 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3009 mL
50 mM 0.0416 mL 0.2082 mL 0.4163 mL 1.0408 mL
60 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
80 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6505 mL
100 mM 0.0208 mL 0.1041 mL 0.2082 mL 0.5204 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trifluoperazine440-17-5盐酸三氟拉嗪甲哌氟丙嗪三氟吡拉嗪Dopamine ReceptorAdrenergic ReceptorCaMKP-glycoproteinInfluenza VirusAutophagyBeta ReceptorCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243antipsychoticanticancerNUPR1schizophreniamorphogenesisInhibitorinhibitorinhibit

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