Trifluoperazine dimaleate  (Synonyms: 三氟拉嗪二马来酸酯)

Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis^{[1][2][3][4][5]}.

Trifluoperazine dimaleate 是一种广泛使用的抗精神病剂。Trifluoperazine dimaleate 已被广泛研究用作钙调蛋白抑制剂^[3][4]。
Trifluoperazine dimaleate 通过干扰细胞 CaM 和/或 CaM 依赖性功能作为流感病毒形态发生的可逆抑制剂^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

639.64

C₂₉H₃₂F₃N₃O₈S

605-75-4

三氟拉嗪二马来酸酯

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70.  [Content Brief]

  [2]. Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28.  [Content Brief]

  [3]. Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545.  [Content Brief]

  [4]. Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22.  [Content Brief]

  [5]. Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160.  [Content Brief]