2. Antibody-drug Conjugate/ADC Related
  3. Peptide-Drug Conjugates (PDCs)
  4. PhAc-ALGP-Dox

PhAc-ALGP-Dox 是一种 肽-药物偶联物，是一种新型抗肿瘤前药，对于TNBC (E0771)、正常小鼠上皮 (HC-11)、人类TNBC (MDA-MB-231 和 MDA-MB-468)、人类结直肠癌 (LS 174T) 和正常人类上皮 (HME-1) 细胞的 IC50 值范围从 311 nM 到 34.25 μM 不等。

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PhAc-ALGP-Dox Chemical Structure

PhAc-ALGP-Dox Chemical Structure

CAS No. : 1616592-31-4

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PhAc-ALGP-Dox 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells[1].
体外研究
(In Vitro)

PhAc-ALGP-Dox 通过一个肿瘤特异性的两步切割过程依次被激活，首先由细胞外的 THOP1 启动切割，然后由 FAPα/DPP4 进一步处理[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PhAc-ALGP-Dox 相关抗体:
分子量

1003.94

Formula

C45H58N5O19P
CAS 号
Sequence

{Phosphonoacetyl}-Ala-Leu-Gly-Pro-{Dox}
Sequence Shortening

{Phosphonoacetyl}-ALGP-{Dox}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PhAc-ALGP-Dox 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PhAc-ALGP-Dox1616592-31-4Peptide-Drug Conjugates (PDCs)doxorubicinDoxFAPαDPP4metastaticTNBCMDA-MB-468MDA-MB-231Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P10760
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