Phomoxanthone A

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Phomoxanthone A 是一种黄酮二聚体，可从 Phomopsis 中分离得到。Phomoxanthone A 对恶性疟原虫 Plasmodium falciparum (K1，耐多药菌株，IC₅₀ 为 0.11 µg/mL) 和结核分枝杆菌 Mycobacterium tuberculosis (H37Ra 菌株，MIC 为 0.50 µg/mL) 具有抗疟和抗结核活性。Phomoxanthone A 在 KB、BC-1 和 Vero 细胞中表现出细胞毒性，IC₅₀ 分别为 0.99、0.51 和 1.4 µg/mL。

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Phomoxanthone A Chemical Structure

CAS No. : 359844-69-2

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

生物活性
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参考文献

生物活性

Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.58 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
A2780	IC₅₀	0.75 μM Compound: PXA	Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
A2780	IC₅₀	1.01 μM Compound: PXA	Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
A2780	IC₅₀	1.18 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31443950]
A2780	IC₅₀	1.44 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	0.86 μM Compound: PXA	Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
A2780cisR	IC₅₀	1.18 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	1.25 μM Compound: PXA	Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
A2780cisR	IC₅₀	1.37 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	1.88 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31443950]
BC1 cell line	IC₅₀	0.51 μg/mL Compound: 1	Cytotoxicity against human BC1 cells by SRB assay Cytotoxicity against human BC1 cells by SRB assay	[PMID: 11520217]
CAL-27	IC₅₀	5.25 μM Compound: PXA	Antiproliferative activity against human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
HCT-116	IC₅₀	1.82 μM Compound: PXA	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	2.04 μM Compound: PXA	Antiproliferative activity against human cisplatin resistant J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human cisplatin resistant J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	2.75 μM Compound: PXA	Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.12 μM Compound: PXA	Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.23 μM Compound: PXA	Antiproliferative activity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	3.34 μM Compound: PXA	Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.75 μM Compound: PXA	Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
K562	IC₅₀	1.86 μM Compound: PXA	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
KB	IC₅₀	0.99 μg/mL Compound: 1	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 11520217]
KYSE-510	IC₅₀	0.76 μM Compound: PXA	Antiproliferative activity against human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
KYSE-510	IC₅₀	0.79 μM Compound: PXA	Antiproliferative activity against human cisplatin resistant KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human cisplatin resistant KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
MDA-MB-231	IC₅₀	3.7 μM Compound: PXA	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
MDA-MB-231	IC₅₀	4.37 μM Compound: PXA	Antiproliferative activity against cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
Vero	IC₅₀	1.4 μg/mL Compound: 1	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 11520217]

分子量

750.70

Formula

C₃₈H₃₈O₁₆

CAS 号

359844-69-2

结构分类

初始来源

微生物

Endophytic Fungus Phomopsis Species

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Isaka M, et al., Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. J Nat Prod. 2001 Aug;64(8):1015-8. [Content Brief]

Phomoxanthone A 相关分类

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质量		浓度		体积		分子量 *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phomoxanthone A359844-69-2ParasiteAntimalarialantitubercularPlasmodium falciparumMycobacterium tuberculosisK1H37RaKBBC-1VeroInhibitorinhibitorinhibit

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Phomoxanthone A

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