2. PI3K/Akt/mTOR TGF-beta/Smad
  3. Akt TGF-β Receptor
  4. Phosphatidylserine

Phosphatidylserine  (Synonyms: Phospholipids, phosphatidylserines; Serine glycerophosphatides)

目录号: HY-A0183 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Phosphatidylserine (Phospholipids) 是一种保守的抗炎和免疫抑制信号。Phosphatidylserine 参与膜易位和蛋白激酶C的激活，通过与 PIP3 的相互作用参与 Akt 信号传导。Phosphatidylserine 的局部暴露可以与补体和其他蛋白质相互作用，在突触细化的发育关键时期促进小胶质细胞吞噬。Phosphatidylserine 在胞外可以促进血液凝固，并作为“吃掉我”信号来清除凋亡细胞。 Phosphatidylserine 可以通过诱导 TGF-β 分泌来抑制组织中的炎症，抑制免疫反应。

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Phosphatidylserine Chemical Structure

Phosphatidylserine Chemical Structure

CAS No. : 1446756-47-3

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5 mg（50 mg/mL * 100 μL in Chloroform） ￥1500
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10 mg（50 mg/mL * 200 μL in Chloroform） ￥2400
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25 mg（50 mg/mL * 500 μL in Chloroform） ￥4800
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Phosphatidylserine 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses[1][2][3][4][5].
体外研究
(In Vitro)

Phosphatidylserine 可以通过诱导 TGF-β 分泌来抑制组织中的炎症，从而避免通过产生调节性 T 细胞来激活免疫反应[2] 。
Phosphatidylserine 可以促进神经元存活分化和突触神经传递[3]。
Phosphatidylserine 的局部外化可以介导小胶质细胞发育突触的修剪[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Phosphatidylserine 相关抗体:
体内研究
(In Vivo)

Phosphatidylserine (0.5 mg 脂质体; 单剂量; 皮下注射) 可以与 PC 和胆固醇以 30:30:40 的摩尔比组成脂质体，脂质体通过结合并增强 Phosphatidylserine 受体的激活来抑制体内免疫反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cAnN and C57BL/6 male mice[2].
Dosage: Phosphatidylserine (PS) liposomes (0.5 mg of total lipid, PS-containing liposomes consisted of 30:30:40 molar ratio PS to PC to cholesterol)
Administration: Subcutaneous injection (s.c.); single dose
Result: Inhibited responses to Ags as determined by decreased draining lymph node tissue mass, with reduced numbers of total leukocytes and Ag-specific CD4+ T cells.
Clinical Trial
分子量

788.10

CAS 号
性状

液体

颜色

Light yellow to yellow

初始来源

Most organisms
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥98.0%

COA (280 KB)

产品使用指南 (1538 KB)
参考文献

Phosphatidylserine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphatidylserine1446756-47-3Phospholipids, phosphatidylserines Serine glycerophosphatidesAktTGF-β ReceptorPKBProtein kinase BTransforming growth factor beta receptorsantiinflammatoryimmunosuppressionlocalized exposurecell phagocytosisInhibitorinhibitorinhibit

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