2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Phosphodiesterase-IN-2

Phosphodiesterase-IN-2 (Compound C7) 是一种口服有效的磷酸二酯酶 10A (PDE10A) 选择性抑制剂，IC50 为 11.9 nM。Phosphodiesterase-IN-2 可以提高肝微粒体的稳定性，降低血脑屏障通透性。Phosphodiesterase-IN-2 在小鼠模型中表现出良好的药代动力学特征，可减轻 Isoprenaline (HY-108353) 诱导的心脏肥厚。

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Phosphodiesterase-IN-2 Chemical Structure

Phosphodiesterase-IN-2 Chemical Structure

CAS No. : 3047610-96-5

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Phosphodiesterase-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline (HY-108353)-induced cardiac hypertrophic in mouse models[1].

IC50 & Target

PDE10A

11.9 nM (IC50)

分子量

584.59

Formula

C32H27F3N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Phosphodiesterase-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphodiesterase-IN-23047610-96-5Phosphodiesterase (PDE)C57BL6/J mousecardiac hypertrophicselectiveorally activeInhibitorinhibitorinhibit

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