1. PI3K/Akt/mTOR Epigenetics Cell Cycle/DNA Damage
  2. HDAC PI3K
  3. PI3Kα/HDAC6-IN-1

PI3Kα/HDAC6-IN-1 (compound 21j) 是 PI3Kα/HDAC6 双重抑制剂,IC50 分别为 2.9 和 26 nM。PI3Kα/HDAC6-IN-1 还抑制 AKT(Ser473) 磷酸化,诱导乙酰化 α-微管蛋白的积累,不影响乙酰化组蛋白 H3 和 H4。PI3Kα/HDAC6-IN-1 高效抑制 L-363 细胞系 (IC50=0.17 μM),抗癌活性好。

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PI3Kα/HDAC6-IN-1 Chemical Structure

PI3Kα/HDAC6-IN-1 Chemical Structure

CAS No. : 3007565-26-3

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  • 生物活性

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生物活性

PI3Kα/HDAC6-IN-1 (compound 21j) is a dual PI3Kα/HDAC6 inhibitor with IC50 of 2.9 and 26 nM, respectively. PI3Kα/HDAC6-IN-1 also inhibits AKT(Ser473) phosphorylation and induces the accumulation of acetylated α-tubulin without affecting acetylated histones H3 and H4. PI3Kα/HDAC6-IN-1 efficiently inhibits L-363 cell line (IC50=0.17 μM) and has good anti-cancer activity[1].

IC50 & Target

IC50: 2.9 nM (PI3Kα), 26 nM (HDAC6)[1]

分子量

669.70

Formula

C27H30F3N7O6S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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产品名称:
PI3Kα/HDAC6-IN-1
目录号:
HY-156091
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