2. PI3K/Akt/mTOR Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. PI3K Reactive Oxygen Species Apoptosis
  4. PI3Kα-IN-8

PI3Kα-IN-8 (Compound 9g) 是一种选择性的 PI3Kα 抑制剂，IC50 为 0.012 μM。PI3Kα-IN-8 增加细胞内活性氧（reactive oxygen species）水平，降低线粒体膜电位，诱导细胞凋亡（apoptosis）。

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PI3Kα-IN-8 Chemical Structure

PI3Kα-IN-8 Chemical Structure

CAS No. : 2315320-24-0

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PI3Kα-IN-8 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis[1].

IC50 & Target

PI3Kα

0.012 μM (IC50)

PI3Kδ

0.11 μM (IC50)

PI3Kγ

0.18 μM (IC50)

PI3Kβ

0.21 μM (IC50)

体外研究
(In Vitro)

PI3Kα-IN-8 (Compound 9g) exhibits anticancer activity with IC50 values of 0.18 ± 0.03, 0.43 ± 0.05, 0.71 ± 0.08 and 0.63 ± 0.09 μM against HCT-116, MCF-7, HeLa and HepG2 cells, respectively[1].
PI3Kα-IN-8 upregulates Bax and cleaved caspase-3/9 levels, and downregulates Bcl-2 level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kα-IN-8 相关抗体:
分子量

507.42

Formula

C26H27BrN4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kα-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-82315320-24-0PI3KReactive Oxygen SpeciesApoptosisPhosphoinositide 3-kinaseHCT-116anticancerMCF-7HeLaHepG2Inhibitorinhibitorinhibit

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目录号：
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