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Pildralazine  (Synonyms: Propyldazine)

目录号: HY-106471
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摩尔计算器

Pildralazine 是一种含游离肼基团的肼类抗高血压血管扩张剂。Pildralazine 具有口服活性，并在小鼠模型中无明显致癌性。

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Pildralazine Chemical Structure

Pildralazine Chemical Structure

CAS No. : 64000-73-3

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Pildralazine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].

体内研究
(In Vivo)

Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay[1].
Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats[2].
Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female B6C3F1 and to female BALB/c mice (8 weeks old)[1]
Dosage: 100, 200, and 400 ppm dose: 8, 20, and 40 mg/kg/day in B6C3F1 males, 8, 22, and 43 mg/kg/day in B6C3F1 females, and 6, 15, and 34 mg/kg/day in BALB/c females, respectively
Administration: Oral gavage; added in the drinking water; provided for 80 weeks, and observed for 130-133 weeks age
Result: Resulted over 80% of mice alive beyond 78 weeks of age.
分子量

197.24

Formula

C8H15N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pildralazine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pildralazine64000-73-3PropyldazineOthersydralazinelikeantihypertensivevasodilatorcarcinogenicityInhibitorinhibitorinhibit

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