2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  3. PPAR Ferroptosis
  4. Pioglitazone potassium

Pioglitazone potassium  (Synonyms: U 72107 potassium)

目录号: HY-13956B
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摩尔计算器

Pioglitazone (U 72107) potassium 是一种具有口服活性的选择性 PPARγ (peroxisome proliferator-activated receptor) 激动剂，高亲和力结合到 PPARγ 配体结合域，作用于人和鼠 PPARγ 的 EC50 分别为 0.93 μM 和 0.99 μM。Pioglitazone potassium 可用于糖尿病研究。

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Pioglitazone potassium Chemical Structure

Pioglitazone potassium Chemical Structure

CAS No. : 1266523-09-4

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Pioglitazone potassium 的其他形式现货产品:

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Pioglitazone potassium 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 29 篇科研文献

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    Pioglitazone potassium purchased from MCE. Usage Cited in: Inflammation. 2020 Apr;43(2):568-578.  [Abstract]

    Colonic lysates of CON + Veh, DSS + Veh, and DSS + PIO (day 7, day 14, and day 21) group mice are analyzed by immunoblotting with IL-6, TNF-α, MMP9, and PPARγ antibodies, respectively. Each lane represents one mouse.

    Pioglitazone potassium purchased from MCE. Usage Cited in: Inflammation. 2020 Apr;43(2):568-578.  [Abstract]

    Colonic lysates of CON + Veh, DSS + Veh, and DSS + PIO (day 7, day 14, and day 21) group mice are analyzed by immunoblotting with p-ERK, ERK, p-P65, and P65 antibodies, respectively. Each lane represents one mouse.

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    PPARα PPARβ/δ PPARγ PPAR PPARδ

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Pioglitazone (U 72107) potassium is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium can be used in diabetes research[2][3][4].

    IC50 & Target[1]

    mouse PPARγ

    0.99 μM (EC50)

    h-PPARγ

    0.93 μM (EC50)

    hPPARδ

    43 μM (EC50)

    hPPARα

    100 μM (EC50)

    mouse PPARα

    100 μM (EC50)

    体外研究
    (In Vitro)

    Pioglitazone potassium (0.5 or 1 μM, 5 days) can completely prevent AGEs (advanced glycation end-products)-induced β-cell necrosis and the increase of caspase-3 thereby avoiding the impaired viability caused by AGEs in pancreatic beta cell line HIT-T15[2].
    Pioglitazone potassium (1 μM, 1 h) can stimulate insulin secretion induced by low glucose concentration and attenuate the GSSG/GSH ratio in cells cultured with AGEs[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Pioglitazone potassium 相关抗体:
    体内研究
    (In Vivo)

    Pioglitazone potassium (oral gavage, 10 or 30 mg/kg, once daily, 14 days) can induce improvements in insulin resistance and diabetes that may be lipocalin-dependent in the liver but not in skeletal muscle[3].
    Pioglitazone potassium (oral gavage, 10 mg/kg, once daily, 4 weeks) can significantly reduce body weight (BW), cardiac hypertrophy, elevated blood glucose levels and improve the associated dyslipidemia[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ob/ob and adipo-/- ob/ob mice with a C57Bl/6 background[3]
    Dosage: 10 or 30 mg/kg
    Administration: Oral gavage; once daily; 14 days
    Result: Showed no changes of serum-free fatty acid and triglyceride levels as well as adipocyte sizes in ob/ob and adipo-/- ob/ob C57BL/6 mice at 10 mg/kg but significantly reduced to a similar degree at 30 mg/kg.
    Also showed no changes of expressions of TNFα and resistin in adipose tissues of ob/ob and adipo-/- ob/ob mice at 10 mg/kg but decreased at 30 mg/kg.
    Animal Model: Male Wistar albino rats[4]
    Dosage: 10 mg/kg
    Administration: Oral gavage; once daily; 4 weeks
    Result: Decreased the elevated serum levels of both creatinine and creatine kinase-MB (CK-MB), TGF-β1 gene expression and regulated the expression of MMP-2/TIMP-2 system.
    Clinical Trial
    分子量

    394.53

    Formula

    C19H19KN2O3S
    CAS 号
    中文名称

    吡格列酮钾盐；酮基匹格列酮钾盐
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Pioglitazone potassium 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pioglitazone1266523-09-4U 72107吡格列酮钾盐酮基匹格列酮钾盐U72107U-72107PPARFerroptosisPeroxisome proliferator-activated receptorsPPARγligand-bindingdomainblood glucosediabeteInhibitorinhibitorinhibit

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