2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. (+)-Perillyl alcohol

(+)-Perillyl alcohol  (Synonyms: (R)-(+)-Perillyl alcohol)

目录号: HY-W747572
产品使用指南 技术支持

(+)-Perillyl alcohol 是 S-(-)-perillyl alcohol (HY-116514) 的对映体。(+)-Perillyl alcohol 能抑制癌细胞生长，将细胞周期阻滞在 G0/G1 期。(+)-Perillyl alcohol 可以诱导细胞信号的传导，且该传导与细胞骨架肌动蛋白组织的改变和生长调节蛋白 (如Ras 和 CDC2 激酶) 的蛋白质表达降低有关。

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(+)-Perillyl alcohol Chemical Structure

(+)-Perillyl alcohol Chemical Structure

CAS No. : 57717-97-2

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规格 价格 是否有货 数量
5 mg ￥1350
1 - 2 周
10 mg ￥2150
1 - 2 周
25 mg ￥4300
1 - 2 周
50 mg 现货 1 - 2 周
100 mg 现货 1 - 2 周
200 mg   询价  
500 mg   询价  

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(+)-Perillyl alcohol 相关抗体

Top Publications Citing Use of Products

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(+)-Perillyl alcohol is the enantiomer of S-(-)-Perillyl alcohol (HY-116514). (+)-Perillyl alcohol can inhibit the growth of polypeptides and block the cell cycle in the G0/G1 phase. (+)-Perillyl alcohol induces cell signaling that is associated with changes in cytoskeletal actin organization and reduced protein expression of growth regulatory proteins such as Ras and CDC2 kinase[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Caco-2 IC50
78.5 μM
Compound: Perillyl alcohol
Cytotoxicity against human Caco-2 cells incubated upto 96 hrs by MTT assay
Cytotoxicity against human Caco-2 cells incubated upto 96 hrs by MTT assay
[PMID: 29126728]
HepG2 IC50
100 μM
Compound: POH
Antiinvasive activity against human HepG2 cells by matrigel-based transwell assay
Antiinvasive activity against human HepG2 cells by matrigel-based transwell assay
[PMID: 30096653]
HT-29 IC50
100 μM
Compound: Perillyl alcohol
Cytotoxicity against human HT-29 cells incubated upto 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells incubated upto 96 hrs by MTT assay
[PMID: 29126728]
MHCC97H IC50
100 μM
Compound: POH
Antiinvasive activity against human MHCC97H cells by matrigel-based transwell assay
Antiinvasive activity against human MHCC97H cells by matrigel-based transwell assay
[PMID: 30096653]
SMMC-7721 IC50
100 μM
Compound: POH
Antiinvasive activity against human SMMC7721 cells by matrigel-based transwell assay
Antiinvasive activity against human SMMC7721 cells by matrigel-based transwell assay
[PMID: 30096653]
T84 IC50
158 μM
Compound: Perillyl alcohol
Cytotoxicity against human T84 cells incubated upto 96 hrs by MTT assay
Cytotoxicity against human T84 cells incubated upto 96 hrs by MTT assay
[PMID: 29126728]
体外研究
(In Vitro)

(+)-Perillyl alcohol (0.25-1 mM) 在 SW480 细胞中抑制细胞生长[1]。
(+)-Perillyl alcohol (1 mM; 24 h)在 SW480 细胞中增加 G0/G1 细胞数量，减少 S 期细胞数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-Perillyl alcohol 相关抗体:
分子量

152.23

Formula

C10H16O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(+)-Perillyl alcohol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Perillyl alcohol57717-97-2(R)-(+)-Perillyl alcoholRasSW480S-(-)-perillyl alcoholInhibitorinhibitorinhibit

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