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  4. PNMT-IN-1

PNMT-IN-1 (inhibtor 4) 是一种特异的PNMT抑制剂，Ki 值为 1.2 nM，IC50 值为 81 nM。PNMT-IN-1也可作用于DNMT1和DNMT3b，IC50 值分别为 61 μM 和17 μM ，同时对肾上腺素有拮抗作用。PNMT-IN-1是第二代抑制剂。

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PNMT-IN-1 Chemical Structure

PNMT-IN-1 Chemical Structure

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PNMT-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a Ki value of 1.2 nM and a IC50 value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC50 value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor[1].

IC50 & Target

IC50:81 nM (Phenylethanolamine N-methyltransferase, PNMT )[1] IC50:61 nM (DNMT1)[1] IC50:17 nM (DNMT3b)[1]
体外研究
(In Vitro)

PNMT-IN-1(inhibtor 4)(0.01 μM, 4h) 抑制PNMT的酶活 (IC50 值为 81 nM) 但是不影响蛋白甲基化。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PNMT-IN-1 相关抗体:

Cell Viability Assay

Cell Line: Overexpressed hPNMT in HEK293T cells using a lentiviral vector[1]
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Inhibted the activity of hPNMT (IC50=81nM)

Western Blot Analysis

Cell Line: HT-29 cell[1]
Concentration: 10 μg
Incubation Time: 6 days
Result: Changed total SDMA, ADMA, and Me3-lysine not significant.
分子量

623.53

Formula

C27H36Cl2N8O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PNMT-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNMT-IN-1OthersOverexpressedlentiviral vectorInhibitorinhibitorinhibit

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产品名称：
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目录号：
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