2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Topoisomerase ADC Cytotoxin
  4. PNU-159682

PNU-159682 GMP 是 GMP 级别的 PNU-159682 (HY-16700)。PNU-159682 是蒽环类新霉素的代谢产物，是一种 DNA 拓扑异构酶 II (Topo II) 抑制剂，具有出色的细胞毒性。在ADC 合成中，PNU-159682 是一种比阿霉素更有效和耐受性更高的 ADC 细胞毒素 (ADC cytotoxin)。PNU-159682 可用于 EDV 纳米细胞技术，克服耐药性。

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PNU-159682 Chemical Structure

PNU-159682 Chemical Structure

CAS No. : 202350-68-3

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PNU-159682 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

查看 ADC Cytotoxin 亚型特异性产品:

查看所有亚型
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

分子量

641.62

Formula

C32H35NO13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PNU-159682 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNU-159682 (GMP)202350-68-3TopoisomeraseADC CytotoxinADC PayloadADCs ToxinNMS249EDV nanocellnon-Hodgkin’s lymphomaNHLacute myeloid leukemiaAMLInhibitorinhibitorinhibit

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目录号：
HY-16700G
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