1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. PNU 37883 hydrochloride

PNU 37883 hydrochloride  (Synonyms: PNU 37883A)

目录号: HY-108589 纯度: 99.66%
COA 产品使用指南 技术支持

PNU 37883 hydrochloride (PNU 37883A) 是一种选择性血管 ATP 敏感钾 (Kir6, KATP) 通道阻滞剂。PNU 37883 hydrochloride 具有利尿作用,特异性结合肾脏和血管平滑肌,而不是大脑或胰腺 β 细胞。

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PNU 37883 hydrochloride Chemical Structure

PNU 37883 hydrochloride Chemical Structure

CAS No. : 57568-80-6

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].

体外研究
(In Vitro)

In HEK-293 cells stably expressing Kir6.2/SUR1, Kir6.2/SUR2A, Kir6.2/SUR2B or Kir6.1/SUR2B, PNU-37883A inhibits four types of KATP channels, but to different extents. Inhibition of the putative smooth muscle KATP channel types, Kir6.2/SUR2B (IC50 of 15 μM) and Kir6.1/SUR2B (IC50 of 6 μM). PNU-37883A significantly inhibits currents generated by expressing Kir6.2Δ26 alone, with an IC50 of 5 μM, which was significantly increased to 38 μM when Kir6.2Δ26 is expressed with SUR2B[1].
PNU 37883 (0.1-10 nM) hydrochloride produces a concentration-dependent attenuation of the relaxation of agmatine (100 μM) in phenylephrine- or KCl- precontracted aortic rings. However, treatment with PNU 37883 (10 nM) hydrochloride alone does not modify the vascular tone[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

381.98

Formula

C21H36ClN3O

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 8.33 mg/mL (21.81 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6179 mL 13.0897 mL 26.1794 mL
5 mM 0.5236 mL 2.6179 mL 5.2359 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6179 mL 13.0897 mL 26.1794 mL 65.4485 mL
5 mM 0.5236 mL 2.6179 mL 5.2359 mL 13.0897 mL
10 mM 0.2618 mL 1.3090 mL 2.6179 mL 6.5448 mL
15 mM 0.1745 mL 0.8726 mL 1.7453 mL 4.3632 mL
20 mM 0.1309 mL 0.6545 mL 1.3090 mL 3.2724 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PNU 37883 hydrochloride
目录号:
HY-108589
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