2. PROTAC
  3. Ligands for E3 Ligase
  4. Pomalidomide-6-O-CH3

Pomalidomide-6-O-CH3 是一种基于 Pomalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体，用于募集 cereblon 蛋白。Pomalidomide-6-O-CH3 可通过 linker 连接到蛋白质配体上形成 PROTAC。

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Pomalidomide-6-O-CH3 Chemical Structure

Pomalidomide-6-O-CH3 Chemical Structure

CAS No. : 1547163-08-5

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Pomalidomide-6-O-CH3 相关抗体

Top Publications Citing Use of Products

查看 Ligands for E3 Ligase 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-6-O-CH3 相关抗体:
分子量

303.27

Formula

C14H13N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pomalidomide-6-O-CH3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-6-O-CH31547163-08-5Ligands for E3 LigaseE3 ligase-recruiting MoietyCRBNPROTACPomalidomideInhibitorinhibitorinhibit

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