2. Anti-infection
  3. Antibiotic
  4. Posizolid

Posizolid  (Synonyms: AZD2563; AZD5847)

目录号: HY-15993
产品使用指南 技术支持

Posizolid (AZD2563) 是一种 oxazolidinone 抗生素，由 AstraZeneca 开发用于研究细菌感染。Posizolid 具有很好的抗 mycobacterial 活性。

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Posizolid Chemical Structure

Posizolid Chemical Structure

CAS No. : 252260-02-9

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Posizolid 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity[1].

IC50 & Target

Oxazolidinone

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero IC50
> 64 μg/mL
Compound: AZD5847
Cytotoxicity against African green monkey Vero cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28523106]
体外研究
(In Vitro)

Posizolid is determined the activity of against 250 highly resistant pneumococci and 267 drug-susceptible isolates. Posizolid MICs for 50 and 90% of the strains tested are 1 and 2 μg/ml and 0.5 and 1 μg/ml, respectively, for the two isolate groups[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Posizolid 相关抗体:
体内研究
(In Vivo)

AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule.
In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3].
Dosage: 3, 10, 30, 100, 300, 600, and 900 mg/kg
Administration: oral; collect blood samples at 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, and 24 h
Result: AZD5847 DSP can’t be detected in plasma 5 min.
Animal Model: Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3].
Dosage: 250 mg/kg
Administration: oral; collect blood and BAL fluid samples at 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 16 h, 24 h, and 48 h
Result: AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h.
分子量

465.40

Formula

C21H21F2N3O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Posizolid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Posizolid252260-02-9AZD2563 AZD5847AZD 2563AZD-2563AZD5847AZD 5847AZD-5847AntibioticoxazolidinoneantibioticAstraZenecabacterial infectionsanti-mycobacterial activityInhibitorinhibitorinhibit

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