2. Anti-infection
  3. Antibiotic
  4. Posizolid

Posizolid  (Synonyms: AZD2563; AZD5847)

目录号: HY-15993
产品使用指南

摩尔计算器

Posizolid (AZD2563) 是一种 oxazolidinone 抗生素，由 AstraZeneca 开发用于研究细菌感染。Posizolid 具有很好的抗 mycobacterial 活性。

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Posizolid Chemical Structure

Posizolid Chemical Structure

CAS No. : 252260-02-9

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Posizolid 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity[1].

IC50 & Target

Oxazolidinone

 

体外研究
(In Vitro)

Posizolid is determined the activity of against 250 highly resistant pneumococci and 267 drug-susceptible isolates. Posizolid MICs for 50 and 90% of the strains tested are 1 and 2 μg/ml and 0.5 and 1 μg/ml, respectively, for the two isolate groups[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Posizolid 相关抗体:
体内研究
(In Vivo)

AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule.
In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3].
Dosage: 3, 10, 30, 100, 300, 600, and 900 mg/kg
Administration: oral; collect blood samples at 5 min, 10 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, and 24 h
Result: AZD5847 DSP can’t be detected in plasma 5 min.
Animal Model: Male BALB/c mice, aged 6 to 8 weeks, 30 to 40 g[3].
Dosage: 250 mg/kg
Administration: oral; collect blood and BAL fluid samples at 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 16 h, 24 h, and 48 h
Result: AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h.
分子量

465.40

Formula

C21H21F2N3O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Posizolid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Posizolid252260-02-9AZD2563 AZD5847AZD 2563AZD-2563AZD5847AZD 5847AZD-5847AntibioticoxazolidinoneantibioticAstraZenecabacterial infectionsanti-mycobacterial activityInhibitorinhibitorinhibit

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