2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPARδ agonist 11

PPARδ agonist 11 (Compound 11) 是 PPARδ 的选择性激动剂，EC50 为 20 nM。PPARδ agonist 11 可以降低 LPS (HY-D1056)-刺激的 RAW264.7 细胞中一氧化氮 (NO)、促炎细胞因子 TNFα 和 IL-6 的水平，并通过 NF-κB 通路表现出抗炎作用。PPARδ agonist 11 在人肝微粒体和血浆中表现出良好的稳定性。PPARδ agonist 11 可改善 Carrageenan (HY-125474)-引起的足部水肿，并表现出良好的药代动力学特征，生物利用度约为100％。

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PPARδ agonist 11 Chemical Structure

PPARδ agonist 11 Chemical Structure

CAS No. : 2982696-04-6

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PPARδ agonist 11 相关抗体

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPARδ agonist 11 (Compound 11) is a selective agonist for PPARδ with an EC50 of 20 nM. PPARδ agonist 11 reduces the levels of nitrite oxide (NO), proinflammatory cytokines TNFα and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 cell, and exhibits anti-inflammatory efficacy via NF-κB pathway. PPARδ agonist 11 exhibits good stability in human liver microsomes and plasma. PPARδ agonist 11 ameliorates Carrageenan (HY-125474)-induced foot edema, and exhibits good pharmacokinetic characteristics with an bioavailability of ca. 100%[1].

IC50 & Target

hPPARδ

0.02 μM (EC50)

hPPARα

8 μM (EC50)

分子量

440.46

Formula

C19H15F3N2O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPARδ agonist 11 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

PPARδ agonist 112982696-04-6PPARδ agonist11PPARδ agonist-11PPARPeroxisome proliferator-activated receptorsSprague-Dawley ratedemaRAW264.7C57BL/6 mouseInhibitorinhibitorinhibit

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